This website serves as the supplement to Large-Scale Mapping and Validation of Escherichia coli Transcriptional Regulation from a Compendium of Expression Profiles, PLoS Biology 2007. Our paper had two major goals. The first was to create a means to determine the relative merits of different network inference algorithms in an unbiased manner on experimental data. The second was to use the network inferred by the best current algorithm to identify novel biology and thereby demonstrate the practical application of network inference software.
On this site, we provide the algorithms, validation scripts, and microarray data described in the paper. With these tools, you can build a network with your own microarray data or test/compare your new network inference algorithm’s performance against ours. Custom dataset construction and data browsing can be done at M3D.