We are developing algorithms and methods to facilitate the design of novel biosynthetic pathways, and to predict the outcome of genetic, media and feedstock changes on biosynthesis.

This work includes:
- Genetic engineering of microbes for increased electricity or fuel production
- Metabolic pathway identification and optimization for biosynthesis or bioremediation
- Mapping of regulatory networks and their impact on metabolic processes

Bacteria are tiny, but powerful chemical factories. In order to support their energy and resource demands, microbes catalyze vast array of chemical reactions. Through clever manipulation of microbial metabolism, the extraordinary catalytic potential of microbes can be tapped to create usable energy and to produce valuable chemicals, drugs and materials.

For example, several microbial organisms have been used in fuel cells to generate electricity directly from chemical nutrient sources. Microbes can even generate this electricity from raw sewage while simulateously detoxifying the waste. Such capabilities mean that one day water treatment facilities may be able generate power to run themselves and nearby homes and businesses.

With the support of the US Department of Energy, we are applying these techniques to one of the electrogenic organisms, Shewanella oneidensis, to increase its current production abilities.